Abstract: The increasingly serious energy exhaustion and environmental pollution accelerates the development of clean hydrogen energy. Water splitting via photocatalysis technology provides an economical and clean way for the hydrogen production, converting solar energy into chemical energy through photocatalytic means is also a promising technical means. The rational selection of photocatalyst is the critical step for obtaining hydrogen energy in an efficient and economical way. Featuring the traits of large specific surface area, adjustable pore size, easy structure modification and abundant active sites, metal-organic frameworks (MOFs) are ideal candidates for photocatalytic hydrogen production scientists from domestic and foreign have carried out numerous researches on the water splitting with MOF-based photocatalysts. Currently, fruitful progresses have been achieved. In this paper, the state-of-the-art advances for the MOF-based materials as catalysts in the field of hydrogen production from splitting water was reviewed, and the advantages and limitations of MOFs as catalysts were summarized. The development prospect of MOFs and related materials in the field of photocatalytic hydrogen production was proposed, providing a valuable guideline for developing future photocatalysts.