Abstract: Accurately predicting and controlling the process-induced deformation of a variable stiffness structure is a key to obtain a reasonable variable stiffness design, the process-induced deformation of a composite structure will not only affect the stiffness and strength of the structure, but also affect the assembly performance of the structure. Based on the automatic placement technology, a process-oriented tow-course-panel multi-level three-dimensional variable stiffness finite element model algorithm was proposed. Combining the Kamal autocatalytic reaction curing kinetic model and the generalized Maxwell viscoelastic constitutive model for thermo-chemical-mechanical multi-field coupling analysis, the changes in the internal temperature field, curing degree field and residual stress field of the structure during the curing process were calculated, and the curing deformation of the variable stiffness structure was finally obtained. The results show that: when T₀=45°, T₁<T₀, the curing deformation of the variable stiffness structure increases with the increase of T₁. When T₁>T₀, the curing deformation of the variable stiffness structure decreases with the increase of T₁. The 100% coverage rule effectively reduces the curing deformation of the structure, while the 0% coverage rule increases the curing deformation. The method proposed in this paper can effectively predict the effect of process parameters on the process-induced deformation of variable stiffness structures.