Abstract: A grid-honeycomb hybrid core was proposed and investigated to address the disadvantage of poor impact resistance of traditional composite sandwich structures. The impact test system of hemisphere-head drop hammer was used to study the low-speed impact response of the carbon fiber aluminum honeycomb sandwich structure. Based on the nonlinear constitutive and perfect interface assumption, the low-speed impact simulation model of the carbon fiber aluminum honeycomb sandwich panel was established and investigated. Research shows that the experimental and simulation results are in good agreement. Finally, the failure mode and mechanical response of grid-reinforced honeycomb hybrid core sandwich panels under different impact positions and impact angles were studied. The results show that there are huge differences in structural damage modes and energy absorption modes under different impact positions and different impact angles. The grid-honeycomb hybrid core can significantly improve the low-speed impact resistance of the structure, and has a good limiting effect on impact damage.